�Shire Limited (LSE: SHP, NASDAQ: SHPGY), the spherical specialty biopharmaceutical company, has announced that VYVANSE is now available in U.S. pharmacies countrywide in ternary additional dosage strengths, delivery the number number to six: 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, and 70 mg. The expanded VYVANSE dosing options will allow physicians to individualise treatment for each affected role. VYVANSE, which received FDA approval for the treatment of ADHD in children in 2007, was besides recently sanctioned to treat ADHD in adults.
VYVANSE is the first prodrug stimulant approved to treat ADHD and was shown to provide consistent livery of participating medication from patient to patient. In clinical studies of VYVANSE in children and adults, VYVANSE showed significant improvement in the core ADHD symptoms of inattention, hyperactivity, impulsivity. In children, VYVANSE demonstrated significant efficacy end-to-end the day, even at 6pm, as reported by parents.
VYVANSE Has Nationwide Formulary Coverage
Since the availability of VYVANSE a year ago to process children with ADHD, VYVANSE has achieved a U.S. market share of more than than 8 percent based on weekly branded prescription volume, with an mean second quarter 2008 mart share of 7.4 percent. VYVANSE formulary coverage has been positive; the top 6 managed care plans now cover the product in a preferred formulary position, and as of June 30, 2008, Shire has executed agreements with nine-spot of the top 11 managed care organizations. At a national level, more than than 92 percent of VYVANSE prescriptions are sanctioned without restrictions (which means without requiring any extra steps from the dr. or patient), and VYVANSE has a competitive copay among covered formulary plans.
ADHD May Affect Adults in All Aspects of Daily Life
Although many people tend to think of ADHD as a childhood problem, up to 65 percent of children with ADHD crataegus oxycantha still march symptoms into adulthood. The disorder is estimated to affect 4.4 pct of U.S. adults aged 18-44 based on results from the National Comorbidity Survey Replication, a nationally representative family survey, which used a lay-administered diagnostic interview to assess a wide mountain chain of DSM-IV disorders. When this share is extrapolated to the full U.S. population, roughly 9.8 million adults are believed to have ADHD.
"The prevalence of ADHD is concerning to the medical community. ADHD may affect adults in their professional life, social life, and relationships," aforementioned Greg Mattingly, M.D., associate clinical professor at the department of psychiatry at Washington University School of Medicine in St. Louis, Mo. "VYVANSE is a recently approved ADHD treatment option for the adult population. In a clinical study with adults, VYVANSE was shown, within the first workweek, to significantly improve ADHD symptoms, inattention, such as the power to stress and get up, and hyperactivity and impulsivity, such as restlessness, and interrupting."
VYVANSE is a therapeutically inactive prodrug, in which d-amphetamine is covalently bonded to l-lysine, and after oral ingestion it is born-again to pharmacologically active d-amphetamine. The conversion of VYVANSE to d-amphetamine is not affected by gastrointestinal pH and is unlikely to be affected by alterations in normal GI transit times.
Additional information about VYVANSE and Full Prescribing Information are available at http://www.vyvanse.com.
About VYVANSE�
Vyvanse is indicated for the treatment of ADHD. Efficacy based on two controlled trials in children ripened 6 to 12 and one controlled trial in adults.
Tell the medico about whatsoever heart conditions, including structural abnormalities, that you, your child, or a family member, may have. Inform the doctor immediately if you or your child develops symptoms that advise heart problems, such as chest pain sensation or fainting.
Vyvanse should not be taken if you or your child has advance disease of the blood vessels (arterial sclerosis); symptomatic heart disease; contain to spartan high blood pressure; overactive thyroid gland (hyperthyroidism); known allergy or unusual reactions to drugs called sympathomimetic amines (for example, pseudoephedrine); seizures; glaucoma; a history of problems with alcohol or drugs; agitated states; taken a monoamine oxidase inhibitor (MAOI) within the last 14 days.
Tell the doctor before taking Vyvanse if you or your baby is existence treated for or has symptoms of depression (sadness, worthlessness, or hopelessness) or bipolar disorderliness; has abnormal thought or visions, hears abnormal sounds, or has been diagnosed with psychosis; has had seizures or abnormal EEGs; has or has had high blood pressure; exhibits aggressive behavior or aggression. Tell the doctor immediately if you or your child develops any of these weather condition or symptoms while taking Vyvanse.
Abuse of amphetamines may lead to dependency. Misuse of amphetamine may cause sudden death and serious cardiovascular adverse events. These events have too been reported rarely with amphetamine purpose.
Vyvanse was generally well tolerated in clinical studies. The most common side of meat effects reported in studies of Vyvanse were: children - reduced appetite, difficulty falling numb, stomachache, and irritability; adult - reduced appetite, difficulty falling asleep, and dry mouth.
Aggression, new abnormal thoughts/behaviors, passion, growth suppression, worsening of motion or verbal tics, and Tourette's syndrome experience been associated with usance of drugs of this type. Tell the doctor if you or your child has blurred vision while pickings Vyvanse.
About ADHD
ADHD is one of the most coarse psychiatric disorders in children and adolescents. Approximately 7.8 percent of all school-aged children, or about 4.4 million U.S. children senior 4 to 17 geezerhood, have been diagnosed with ADHD at some point in their lives, according to the Centers for Disease Control and Prevention (CDC). The disorder is also estimated to affect 4.4 percent of U.S. adults aged 18-44 based on results from the National Comorbidity Survey Replication, a nationally example household survey, which used a lay-administered diagnostic interview to access a wide range of DSM-IV disorders. When this percentage is extrapolated to the full U.S. population, approximately 9.8 one thousand thousand adults ar believed to have ADHD. ADHD is a neurobiological disorder that manifests as a persistent pattern of inattention and/or hyperactivity-impulsivity that is more than frequent and severe than is typically observed in individuals at a corresponding level of development. To be right diagnosed with ADHD, a child of necessity to demonstrate at least six of nine symptoms of inattention; and/or at least six-spot of baseball club symptoms of hyperactivity/impulsivity; the onset of which appears before age 7 age; that some impairment from the symptoms is present in iI or more settings (e.g., at school and home); that the symptoms continue for at least six months; and that there is clinically substantial impairment in social, academic, or occupational functioning and the symptoms cannot be better explained by another psychiatric upset.
Although there is no "cure" for ADHD, there are recognized treatments that specifically target its symptoms. The almost common standard treatments include educational approaches, psychological, or behavioral modification, and medication.
Shire Limited
Shire's strategic goal is to become the leading specialism biopharmaceutical company that focuses on get together the needs of the specialist doc. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as well as opportunities in other remedial areas to the extent they arise through acquisitions. Shire's in-licensing, amalgamation and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights. Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and comparatively small-scale gross revenue forces will deliver potent results.
For further information on Shire, please visit the Company's website: hTTP://www.shire.com.
"Safe Harbor" Statement Under The Private Securities Litigation Reform Act Of 1995
Statements included herein that are not historical facts are modern statements. Such forward-looking statements involve a number of risks and uncertainties and are national to change at whatever time. In the result such risks or uncertainties materialize, the Company's results could be materially moved. The risks and uncertainties include, simply are not limited to, risks associated with: the inherent uncertainty of pharmaceutical research, product development, manufacturing and commercialisation including, just not limited to, the establishment in the marketplace of VYVANSE� (lisdexamfetamine dimesylate) (Attention Deficit and Hyperactivity Disorder ("ADHD")); the impact of private-enterprise products, including, but non limited to, the impact of those on the Company's ADHD franchise; patents, including but not limited to, legal challenges relating to the Company's ADHD franchise; government regulation and approval, including but non limited to the expected product approval date of INTUNIV� (guanfacine extended spill) (ADHD); the Company's power to secure new products for commercialisation and/or development; the Company's proposed pop the question for Jerini AG, including but non limited to, the Company's ability to successfully complete the offer and integrate Jerini AG, as well as realize the hoped-for benefits of the acquisition; and other risks and uncertainties elaborated from time to time in the Company's filings with the Securities and Exchange Commission, including the Company's Annual Report on Form 10-K for the year complete December 31, 2007.
Shire Limited
View dose information on Vyvanse.
More information
Sunday, 7 September 2008
Thursday, 28 August 2008
LL Cool J Challenges President Bush, Reaches Out To Bon Jovi Fans In Exit 13
The album cover of LL Cool J's Exit 13 depicts a giant microphone crashing into a highway and literally cracking the asphalt. The 24-year hip-hop vet describes the artwork as him spiking the mic, the way a football player would spike the ball after grading a touchdown. He's notion that victorious about the project.
"It's a pressure inside of me," LL aforesaid, sitting in Manhattan's Chung King Studios, the facility in which he recorded so many of his hit records. "I feel like a champagne feeding bottle that got shook up. I'm all excited around people audience it, because I want them to know how much I love my music. There's only one way to prove it. It's non about organism old school or new school; it's about organism classic. I'm not rattling interested in all that 'legend' and 'icon.' It's cool. I mention it here and there, but I really wanna make a hot joint. If I never made an album before, I think this album would be hot. When there's pressure situations, I ordinarily deliver."
"Baby" with The-Dream is the current single from hip-hop's G.O.A.T. On the album, he also has a version of the track featuring Jon Bon Jovi's wingman.
"I have a remix of 'Baby' with Richie Sambora, which is a john Rock joint," he explained. "[It] is dotty but it's unconventional. I wanted to take it to another level and do something different and touch some of those people world Health Organization like me when I do that rock-edge spirit. I got a whole crew of people out there wHO heard me on the Howard Stern ["Private Parts"] soundtrack with the [Red Hot] Chili Peppers playing behind me.
"The remix is hot," he added. "We creatively assign our heads together. I told him I wanted that babble out box. Slippery When Wet by Bon Jovi's is one of my front-runner albums. I thought the talk box on a couple of the songs was unbelievable, 'Livin' on a Prayer' especially. So, I got Richie to do it on the 'Baby' remix. It sounds crazy. Then he did some vocals, and he did some guitar solos ... so it's good. I'mma drop it out there, shoot it out there and give way people a chance to feel it. We been talking around it, having some in effect conversations."
Among the other appearances on Exit 13 are 50 Cent on "Feel My Heart Beat" and Wyclef Jean on "Mr. President."
"I thought his voice would do that song so much doJ," Uncle L said of Wyclef. "It resonates. It has that truthful vigor to it, that pain in the neck. I wrote a song that fundamentally, it's a letter to the president. If I had an opportunity to have a conversation with him, I'd pose a few questions to him in a respectful personal manner � because I think that, as a community, we tin can get further with me asking him questions in a respectful manner than me talk crazy. Instead of me starting a bunch of ruckus, I pose a bunch of questions that I thought were fairly intelligent to him, and we'll see if there's a response that comes back. [The questions] are relevant to our current president and at the same time could be posed to a president that comes in office after Bush, because none of the problems volition be resolved. They're pretty timeless questions."
To start the record off, he raps, "Dear Mr. President, with all due respect/ Wish we could have a conversation./ I would take a trip downcast to your residence, and we would talk around the state of the nation."
Later LL addresses the war in Iraq: "Don't get me wrong./ I esteem the flag/ But it hurts to see a kid in a eubstance bag./ He fought for his country with all he had./ Now we have a family without a pa./ Lil mama's glaring, the kid's are scared./ On 9/11, wherefore were we unprepared?"
Cool J is one of the many MCs who chimed in when MTV asked how the hip-hop community can support Barack Obama without bringing any minus light to his campaign.
"By being bright," was LL's answer. "You know the man's a politician. They're looking for any flaw to pounce on him. You recognize if there's a drip of blood on him, a shark is gonna come for him. Why would you say anything inflammatory in a record that's meant to support him? It's common sense. I live we're rap. I know it's vanish for us to be rebels. I respect that completely. I'm part of the culture. But there's a time and place for everything. While we're supporting this man, we need to support him in a way that's helpful."
More info
Saturday, 9 August 2008
The Hanson Brothers
Artist: The Hanson Brothers
Genre(s):
Rock: Punk-Rock
Other
Discography:
Brad
Year: 2003
Tracks: 5
My Game
Year: 1999
Tracks: 15
Sudden Death
Year: 1996
Tracks: 15
Gross Misconduct
Year: 1992
Tracks: 17
Tuesday, 1 July 2008
Gabrielle Union - Union Prolongs Parenting To Put Off Adulthood
Actress GABRIELLE UNION has vowed to put motherhood to one side for a few years - because she's not responsible enough to play the demanding role of mother.
The 35-year-old star ended her five-year-long marriage to American football star Chris Howard in 2006.
And Union admits the couple never conceived partly because she feared taking on adult responsibilities.
She says, "Right now, I don't have the same urges as other women when they see a baby. When I see children, I see responsibilities, which I don't think I'm quite ready for. I feel the same about puppies. They're cute for a second, but there's a lot of responsibility involved."
See Also
Monday, 23 June 2008
Monday, 16 June 2008
Heather Small
Artist: Heather Small
Genre(s):
Rock: Electronic
Discography:
Proud
Year: 2000
Tracks: 12
Missing Persons
Monday, 9 June 2008
Actor Anderson Dies
Former child actor ROBERT J. ANDERSON has died. He was 75.
The star - famed for his role as the young George Bailey in 1946's It's a Wonderful Life - passed away at his home in Palm Springs, California on Friday (06Jun08) following a long battle with cancer.
Anderson also appeared in the 1940 Shirley Temple film Young People at the tender age of seven.
He leaves a wife, Victoria.
See Also
Sunday, 8 June 2008
REVIEW: Gone Baby Gone (15)
In a year that involved two major missing children cases in the UK, no film resonates the past 12 months in the press more than Ben Affleck’s directorial debut - so it’s understandable that the original UK release date was put back by 6 months.
Based on the Denis Lahane novel of the same name, Casey Affleck plays Patrick McKenzie, a local private investigator in a rough area in Boston. Approached by the family of a missing girl, Patrick and his girlfriend Angie (Michelle Monaghan) throw themselves into the life of this family, unearthing a highly disturbing tale of selfish people and underlining the fact that people will never change.
Along with the local police, captained by the reliably excellent, Morgan Freeman, Patrick has a cagey relationship with the authorities, who resent his involvement in their case. This tense atmosphere is brilliantly alleviated by the blunt but enjoyable dry humour that punctuates this uneasy alliance. Ed Harris punches his weight as the ageing detective set on the case and his banter with Casey Affleck’s character makes for great viewing, as they begin to work together and realise they’re all fighting for the same cause.
But what makes this film so brilliant are the unexpected twists and turns the story that regularly leave you unsettled but never quite sure why. Plus, all the cast are at their best. Casey Affleck captivates again, building on his already impressive CV and proving that he is the most talented acting Affleck. But Amy Ryan, who plays the grieving trailer-trash mother, really steals the show and was rightfully nominated for the Best Supporting Actress Oscar. Her performance is so strong that you can't fail to be haunted by the moral implications of the story as you leave the cinema, forced into a mental tussle that you’ll fight with for many days after.
After almost ten years in the Hollywood 'widerness', Ben Affleck has found his feet with a story that grabs you by the throat and demands that the audience think about the characters' actions long after the credits roll. A bold move by a bold director. So let’s forget Gigli, kick J-Lo to the curb and appreciate Ben Affleck for this unforgettable film.
Based on the Denis Lahane novel of the same name, Casey Affleck plays Patrick McKenzie, a local private investigator in a rough area in Boston. Approached by the family of a missing girl, Patrick and his girlfriend Angie (Michelle Monaghan) throw themselves into the life of this family, unearthing a highly disturbing tale of selfish people and underlining the fact that people will never change.
Along with the local police, captained by the reliably excellent, Morgan Freeman, Patrick has a cagey relationship with the authorities, who resent his involvement in their case. This tense atmosphere is brilliantly alleviated by the blunt but enjoyable dry humour that punctuates this uneasy alliance. Ed Harris punches his weight as the ageing detective set on the case and his banter with Casey Affleck’s character makes for great viewing, as they begin to work together and realise they’re all fighting for the same cause.
But what makes this film so brilliant are the unexpected twists and turns the story that regularly leave you unsettled but never quite sure why. Plus, all the cast are at their best. Casey Affleck captivates again, building on his already impressive CV and proving that he is the most talented acting Affleck. But Amy Ryan, who plays the grieving trailer-trash mother, really steals the show and was rightfully nominated for the Best Supporting Actress Oscar. Her performance is so strong that you can't fail to be haunted by the moral implications of the story as you leave the cinema, forced into a mental tussle that you’ll fight with for many days after.
After almost ten years in the Hollywood 'widerness', Ben Affleck has found his feet with a story that grabs you by the throat and demands that the audience think about the characters' actions long after the credits roll. A bold move by a bold director. So let’s forget Gigli, kick J-Lo to the curb and appreciate Ben Affleck for this unforgettable film.
Will & Grace star agrees film deal
'Will & Grace' star Debra Messing has joined the cast of a new family drama-comedy called 'Humboldt Park'.
Variety reports that the cast of the film also includes John Leguizamo, Alfred Molina, Freddy Rodriguez, Jay Hernandez, Mercedes Ruehl, Luis Guzman, Melonie Diaz and Vanessa Ferlito.
'Humboldt Park' tells the story of three siblings who return to the family home for a festive visit.
Messing will play the wife of Leguizamo's character.
Shooting on the Alfredo De Villa-directed film begins next week in Chicago.
Variety reports that the cast of the film also includes John Leguizamo, Alfred Molina, Freddy Rodriguez, Jay Hernandez, Mercedes Ruehl, Luis Guzman, Melonie Diaz and Vanessa Ferlito.
'Humboldt Park' tells the story of three siblings who return to the family home for a festive visit.
Messing will play the wife of Leguizamo's character.
Shooting on the Alfredo De Villa-directed film begins next week in Chicago.
Sonny and Cher
Artist: Sonny and Cher
Genre(s):
Pop
Other
Discography:
The Wondrous World of Sonny and Cher
Year: 1998
Tracks: 15
Sonny and Cher And Friends: Baby Don't Go
Year: 1965
Tracks: 12
Look At Us
Year: 1965
Tracks: 12
Kate Hudson - Hudson Denies Wilson Engagement Rumours
LATEST: Actress KATE HUDSON has denied rumours she is engaged to OWEN WILSON.
Hudson, 29, was spotted sporting a diamond ring on her wedding finger on Thursday (08May08), fuelling speculation the on-off couple is taking their relationship to the next level.
The pair met on the set of 2006 movie You, Me + Dupree and were romantically linked later that year (06) after Hudson split from her husband of six years, rocker Chris Robinson.
The couple parted ways in June 2007, just two months before Wilson's alleged suicide attempt.
And in recent months the stars have seemingly rekindled their love, spending Easter together in March (08) in Miami, Florida.
But a spokesperson for Hudson has refuted claims the star is engaged, telling UsMagazine.com, "She's definitely not engaged. She's shooting a movie called Bride Wars, which explains the ring."
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Usher's father dies
R&B star Usher's father, Usher Raymond III, passed away at an Atlanta hospital on Friday, according to reports.
People.com say the cause of death was not immediately known and that Usher was unavailable for comment.
The funeral will take place this week at the Taylor funeral home chapel in Chattanooga, Tennessee.
Usher and his wife Tameka recently celebrated the birth of their son, Usher Ramond V.
People.com say the cause of death was not immediately known and that Usher was unavailable for comment.
The funeral will take place this week at the Taylor funeral home chapel in Chattanooga, Tennessee.
Usher and his wife Tameka recently celebrated the birth of their son, Usher Ramond V.
Senor Coconut
Artist: Senor Coconut
Genre(s):
Other
Discography:
El Baile Aleman
Year: 2000
Tracks: 11
Gran Baile Con
Year: 1997
Tracks: 10
For an absurdly comic idea, Señor Coconut proved to have more than than a single preeminence at their -- or perchance his -- disposal, managing two albums and even planning a U.S. tour. German DJ and manufacturer Uwe Schmidt (aka Atom Heart) had released dance music in his mother country under a number of different aliases during the first half of the nineties. But he'd become blase with the European music scene and in 1996 transferred his base of operations to Chile in order to begin exploring the possibilities of Latin music, which was, he said, "a pretty much undiscovered planet to me. It unveils dozens of interesting musical worlds to me." Adopting the ridiculous Señor Coconut soubriquet, he number 1 cooked up El Gran Baile, a distinctly Latin-flavored groove-a-thon, and did a remix for old Deee-Lite turntablist Towa Tei. Then he began to excogitate the possibilities of a German-Latin fusion, and plant his material in the unlikeliest of places -- the sterling hits of man-machine band Kraftwerk, best-known for their very cold-blooded, unemotional approach to euphony -- the very paired of Latin rage. The answer was El Baile Alemán. Although credited to Señor Coconut y Su Conjunto, it was strictly the work of Schmidt and trey vocalists, world Health Organization took the Kraftwerk machine ideal and tipped it on its head, putt in programmed cumbia, merengue, and salsa rhythms to feel the Teutonic brood. Released as a one-off in 2000, it received a fair amount of critical hail in the U.S., more than Schmidt had received for whatsoever of his other work. In March 2001, Señor Coconut -- now a actual eight-piece band -- was position to undertake a short headlining tour in North America, simply visa problems for some of the Chilean musicians forced a cancellation. Two years by and by, however, the band released Feast Songs, which was followed up in 2005 with Coconut FM, a collection of Latin club tunes. Their following album, Yellowed Fever, which not only when covered songs by Yellow Magic Orchestra simply included all threesome members as well as former guest artists, came out in 2006.
Noekk
Artist: Noekk
Genre(s):
Rock: Electronic
Discography:
The Water Sprite
Year: 2005
Tracks: 7
Lost - Lost Star Fox Plans Oregon Escape
Guitar great Jeff Healey dies, 41
Jeff Healey, the Canadian guitarist who sold over a million copies of his debut album 'See the Light' and starred opposite Patrick Swayze in 'Road House', has died.
Healey, who was 41, had battled cancer throughout his life and died on Sunday in Toronto.
As an infant Healey lost his eyesight due to retino blastoma, a rare form of cancer.
He began playing the guitar when he was three-years-old and developed a style of playing the guitar across his lap while seated.
Discovered by the legendary guitarist Stevie Ray Vaughan in a Toronto bar at 15, Healey put together his first band at 17 and later found fame with his trio The Jeff Healey Band.
The trio's debut, 'See the Light', was Grammy-nominated and gave them a US hit with the track 'Angel Eyes'.
Healey explored early jazz on his later albums but had completed work on his first rock and blues album in eight years, 'Mess of Blues'. It was due for release in Europe on 20 March.
He is survived by his wife and two children.
Healey, who was 41, had battled cancer throughout his life and died on Sunday in Toronto.
As an infant Healey lost his eyesight due to retino blastoma, a rare form of cancer.
He began playing the guitar when he was three-years-old and developed a style of playing the guitar across his lap while seated.
Discovered by the legendary guitarist Stevie Ray Vaughan in a Toronto bar at 15, Healey put together his first band at 17 and later found fame with his trio The Jeff Healey Band.
The trio's debut, 'See the Light', was Grammy-nominated and gave them a US hit with the track 'Angel Eyes'.
Healey explored early jazz on his later albums but had completed work on his first rock and blues album in eight years, 'Mess of Blues'. It was due for release in Europe on 20 March.
He is survived by his wife and two children.
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